The therapeutic options after CAR T-cell relapses are limited, emphasizing the need to develop novel therapies to improve current survival rates. Nevertheless, long term studies revealed that some patients treated with CD19 or CD22 CAR T-cells can relapse due to low target antigen expression in tumor cells or to antigen loss. UCART20x22: allogeneic dual CAR T-cells for the treatment of B-cell malignanciesĪutologous CAR T-cell therapies have shown outstanding responses in the treatment of selected blood cancers, predominantly B-cell malignancies. We are proud of the pre-clinical results presented and remain deeply focused on the development of our product candidates to deliver breakthrough treatments that could benefit thousands of patients worldwide,” said André Choulika, Ph.D., Chief Executive Officer at Cellectis. “Our breadth of scientific presence at the 29th ISCT annual event reflects the type of cutting-edge research our teams undertake, which we believe is essential to address patients’ unmet medical need. NEW YORK, J(GLOBE NEWSWIRE) - Cellectis (the “Company”) (Euronext Growth: ALCLS - NASDAQ: CLLS), a clinical-stage biotechnology company using its pioneering gene-editing platform to develop life-saving cell and gene therapies, showcased preclinical data at an oral presentation and two poster presentations at the International Society for Cell & Gene Therapy (ISCT) 29 th annual event that took place at the Paris Convention Center in Paris, France on May 31 - June 3, 2023. Preclinical data on UCART20x22, Cellectis’ first allogeneic dual CAR T-cell product candidate to treat B-NHL, presented at an oral sessionĮncouraging data presented on gene editing process using Cellectis TALEN ® technology to develop highly efficient HBB gene correction of sickle cell mutationĬomprehensive analysis to better design efficient TALE Base Editors (TALE-BE) using Cellectis’ TALEN ® technology presented in a poster
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![]() Then you will add the eggs and the gravy and bake. Increase to medium-high, bring to a simmer, stirring until gravy is thickened. Plan to bake it for an additional 20 minutes, covering it with foil halfway through to prevent over-browning. Stir in flour, salt, and pepper, and slowly add the 2 cups of milk. Yes To make this casserole the night before, prepare it through Step 3, then cover and refrigerate it overnight. For the gravy: melt the butter in a saucepan, over medium heat. In a bowl, mix the eggs, milk, pepper, and salt. Image By: Smokin’ & Grillin’ Wit’ AB Via YouTube Preparation Cut each biscuit into 8 pieces. Line the bottom of the greased pan with half of the biscuit dough. Then, you will fray the sausage and the bacon, and start layering the casserole with all of the awesome ingredients. Open the biscuits and tear each biscuit into four pieces. Add the gravy to the skillet and stir to combine. ![]() In a medium bowl, whisk together the gravy mix and 1 cup of water until smooth. Biscuits are best served warm and golden right out of the oven. In a large skillet, cook the sausage over medium-high heat, breaking it up with a spatula, until browned and cooked through. ![]() You will begin by cutting your biscuits and laying them in the casserole dish. Simply preheat oven to 375 degrees F, place frozen biscuits on ungreased cookie sheet with sides touching, and bake for 20-24 minutes for less than six biscuits or 24-28 minutes for seven or more. In this recipe for biscuits and gravy casserole today by Smokin’ And Grillin’ Wit’ AB on Youtube, you will learn how to make this delicious breakfast casserole in a few easy steps. 2 tablespoons of butter (or you can use bacon grease for a real country flavor) Ingredients For The Biscuits And Gravy With Sausage Casserole Recipe: 1 can of Pillsbury Grands biscuits 6 eggs 1 package of peppered gravy mix 1 pound of.While casserole is cooking, in a small sauce pan, add all of the gravy ingredients and whisk together over medium/high heat until the gravy thickens, remove from heat and when casserole is finished baking, pour over casserole or spoon over each individual serving.Advertisement Ingredients For The Biscuits And Gravy With Sausage Casserole Recipe:.Add sausage to the eggs and stir then add in the biscuit pieces and mix together.In a bowl, whisk together the eggs, milk, salt, black pepper and cornstarch. ingredients 1 (16 1/3 ounce) can jumbo biscuits 1 lb pork sausage 2 cup sweet onion, finely chppped 8 large eggs, beaten 3 cups shredded cheese (such as.1/4 -1/2 teaspoon salt – adjust to taste.1 can of Pillsbury Grands Buttermilk biscuits (8 biscuits) or Homemade biscuits – cut into quarters The most delicious breakfast casserole with sausage gravy that can be slopped up by biscuits I have a weakness for biscuits and sausage gravy.1/2 pound ground sausage – breakfast, sage or mild.What you need to make this biscuits and gravy casserole: I you want to use homemade biscuits here is my biscuit recipe HERE and my white country gravy recipes is HERE. 44K views, 541 likes, 45 loves, 89 comments, 1.1K shares, Facebook Watch Videos from Pillsbury: Make biscuits and gravy even easier by serving it in casserole form Creamy sausage gravy with fluffy. I love homemade flaky biscuits, however, the premade Pillsbury Grand’s buttermilk biscuits I use in this recipe make it so easy and convenient! They taste great and it’s fun to see the layers puff up when this bakes up. I love biscuits and gravy for breakfast or brunch, it’s super nostalgic to me so this dish has my heart. The white gravy is a simple 5 minute gravy that anyone can make. It has sausage, biscuits and a white gravy that gets added over the top after it’s been baked. It’s perfect for a holiday breakfast or brunch or to bring to a morning potluck. This biscuits and gravy casserole has all the goodness of biscuits and gravy but it’s packaged in a easy and convenient casserole dish. We then applied the anchor of the second strip 1 in. After cutting the tape into a Y-shape, we applied the tape head (anchor) of the first strip to the wrist, stretched the tape slightly with approximately 30% of available tension to the tails, laid down the tape ends with no tension, and applied pressure to the tape surface to initiate adhesion. The patient was positioned with the elbow extended and the wrist ulnar deviated and flexed. ![]() The main strip was used to inhibit the targeted muscles while the second strip correct the fascia. , with the main strip applied along the extensor muscles and the second strip vertical to the first one on the proximal forearm (Fig. ![]() We used two Y-shaped Kinesio strips for the KT procedure for lateral epicondylitis as proposed by Kaze et al. The taping was performed by an experienced physical therapist. The color and width of the two tapes were very similar, appearance-wise making it hard to differentiate between them (Fig. The Kinesio Tex Tape was used for KT and the Elastic Adhesive Tape (3 M™) for ST. We hypothesized that KT could provide immediate effects on pain reduction in patients with lateral epicondylitis. Considering that pain measures are usually subjective and might have great inter-individual variability, we used a randomized cross-over design with self-comparator to maximize statistical power from our sample size. We also focused on the immediate effects on pain reduction during dynamic motions in hope of applying the results to the sport fields. We therefore designed this study with a placebo control to investigate the effectiveness of KT on pain relief. However, without a control group, those positive findings can be due to the placebo effect. reported that patients’ pain and grip strength significantly improved after applying KT. In a non-control study with before-after design, Dilek et al. The effectiveness of KT in managing lateral epicondylitis has not been adequately explored. Certainly, well-designed research is warranted so that the practitioners can be confident that KT is beneficial for their patients. ![]() Despite the inconsistencies, some randomized controlled trials have reported that the KT is beneficial in controlling pain in certain conditions such as acute and chronic low-back pain, cervical whiplash, and knee pain after joint replacement. KT may or may not reduce pain in the short-term use when compared with minimal treatment, and not be superior when compared with other interventions in patients with musculoskeletal disorders. The results has been interpreted as either trivial or no effects on muscle strength in healthy adults. Various quality and methodology of the trials has influenced the consistency of results in these reviews. Various clinical effects of KT have been reviewed in a diversity of conditions and populations. Numerous effects of KT are hypothesized, including pain reduction, normalizing muscle function, improving proprioceptive feedback, and correcting articular malalignment. Invented by the Japanese chiropractor Kenzo Kase in the 1970s, the tape is an elastic woven-cotton strip with heat-sensitive acrylic adhesive and the maximum available tension of about 40–60% its overall length. Kinesio taping (KT) is widely used to manage various musculoskeletal problems. In some cases, the recovery phase can be as long as several months, potentially impacting the quality of life and sports performance of affected individuals. Although treatments are usually non-surgical (e.g., oral medications, steroid injections, and physiotherapy), many of them lack sufficient evidence of beneficial effects. This is the result of the degenerative angiofibroblastic hyperplasia of wrist extensor tendons due to repeated microtraumas. It typically presents with pain around the lateral epicondyle elicited by forceful wrist extension. ![]() The dominant upper limb is much more often involved. Lateral epicondylitis (tennis elbow) is the most common cause of elbow pain, and is commonly seen in racquet sports players with a reported incidence of 9~ 35% and a prevalence of 14~ 41% among tennis players. The healing dust is not limited to mob kills. Testing Xeroc armor in Calamity 1.3.3.011 with a Razorpine on multiple Bloom Slimes showed that both the healing and damage dust took effect continuously. The Comet Quasher and Stellar Striker will not work on regular target dummies, you must strike an actual enemy for them to summon their rain of projectiles. ![]() Does the Comet Quasher and its upgrade really work on regular target dummies ( because they seem to not ), or does it have to be some special target dummy? - BalancedLightningEtherial ( talk) 13:46, 4 July 2018 (UTC) Either way, it would be great if anyone could help with this matter. However, when I updated to v1.3.3.11 the next day, the healing magenta dust was either only spawning on mob kills, or much more rarely, now with 10-20 health recovered per heal-dust ( don't know the exact numbers of healing in the previous version ). Now, I don't know whether the dmg/heal dust ratio was a thing or it was both at the same time, but it really did work like both Specter armor set bonuses combined, at least that's how it worked when I fought Providence twice in pre-v1.3.3.11 Calamity version. As the description on the Xeroc armor page on the wiki suggests, magic damage done while Xeroc armor is equipped spawns magenta dust which deals damage to enemies and heals the player. So, I don't know what exactly happened, but since I am currently going through my mage playthrough, I was very excited about acquiring Xeroc armor. Minecat07 ( talk) 14:01, 25 September 2017 (UTC) Xeroc armor description needs a bit of a fix It is indeed from Calamity, and it's mentioned on the Bosses page already. If someone could make a page about this that will be awesome. What I'm trying to say is that the summoning items being sold by NPC might be a feature from the Calamity Mod. The Steampunker sells the mech bosses summon items. The Wizard I think sells the hardmode ones( I defeated only Cryogen so IDK). The Dryad is selling all pre-hardmode summoning items(except Abeemination, sold by the Witch Doctor, and the voodoo dolls sold by. I noticed that whenever I defeat a boss(neither vanilla or Calamity) a certain NPC is selling a summoning item. Solar ( talk) 15:28, 6 June 2021 (UTC) The summoning items Tymon80 ( talk) 08:41, (UTC) Vanilla changes might be what you're looking for. That is what is meant to happen, but people keep redirecting it to Terraria wiki pages. Also, I'm putting this here because I don't know where else to put it, not because I think it's somehow linked to this page. That way, there's 1 page that explains what new mobs spawn there, and a link to the normal page, which would make it much easier to decide if you're ready for a normal Terraria biome yet with this mod installed, because there's one place that tells you what mobs spawn there, and also possibly a "players should not go here until they have this because" note. I think that it's good that topics that already exist in normal Terraria redirect to the Terraria wiki, but I think that already-existing topics, like the cavern layer, should have a short page explaining how the mod has changed the cavern layer (new mobs and stuff), with a link to the Terraria wiki page that explains other stuff.
![]() This can be particularly beneficial for students who struggle with math or who are not confident in their ability to perform calculations without a calculator. Improved ability to teach mental math: Abacus training can provide educators with techniques and strategies for teaching mental math skills to their students.This can help them to better explain these concepts to their students and to identify areas where students may be struggling. ![]() Improved understanding of mathematical concepts: Abacus teacher training can provide educators with a deeper understanding of mathematical concepts and principles.Some of the key benefits of abacus teacher training include: What are the benefits of abacus teacher training for educators?Ībacus teacher training can provide educators with several benefits that can improve their teaching skills and benefit their students. This can help them to inspire and motivate students to achieve their goals and reach their full potential. Dedication to education: Abacus teachers should have a strong dedication to education and a passion for helping students to succeed.This can help to keep students motivated and engaged in the learning process. Creativity: Abacus teachers should be creative and able to develop engaging lesson plans that make learning fun and interactive for students.This requires effective communication skills, including the ability to explain concepts clearly and answer questions in a way that students can grasp. Effective communication skills: Abacus teachers must be able to communicate complex math concepts in a way that students can understand. ![]() A good abacus teacher should be patient and willing to work with students at their own pace.
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I didn’t make it at home because there are only 2 of us and if I really wanted macaroni salad, I could get it at the diner with a sandwich. Macaroni salad is one of those foods I never really had to make because it always appeared at cookouts and family get-togethers. Seriously, all the best foods come from those kitchens! Unfortunately, macaroni salad can’t be frozen because it has a lot of moisture.I really wanted to call this “Southern Gas Station Macaroni Salad” because that’s honestly what it is □ The is the type of macaroni salad found at the little restaurant attached to the “country store” gas station. Do this and it will last for up to five days. If you want your macaroni salad to last longer, keep it in an airtight container in your refrigerator. ![]() If you won’t be eating it in the next hour, keep it in the fridge. ![]() The first rule of macaroni salad is never leave it out at room temperature for too long! Remember, you want to serve this cold. Cherry tomatoes – Tomatoes are a great way to add acidity to your macaroni salad, especially when you’re using extra rich mayonnaise like whole egg or Japanese mayo!.Just like ham, this gives your dish more saltiness too. Bacon bits – It’s impossible to say no to bacon bits! If you want some crunch in your salad, you’re really going to enjoy this add-in.Diced ham – Another protein you can add to your macaroni salad is ham! If you want more satiness, this is the way to go.Grated carrots – For more color and extra sweetness, try adding grated or diced carrots! This is also another great topper to make your dish look even more appetizing.Hard-boiled eggs – You can always use just a bite more protein in your meal so why not try adding some diced hard-boiled eggs?.Cheese – Who doesn’t love a little extra cheese on top of a dish right? Try topping off your macaroni salad with diced cheddar or parmesan! You can even add it in your dressing to make sure every bite is deliciously cheesy.We all love a classic recipe, but if you want to give grandma’s macaroni salad a little twist of your own, here are some delicious add-ins you can try! Make your macaroni salad extra pretty by adding a few bits of chopped red and green pepper on top! Macaroni Salad Add-Ins Here’s a trick you can use if you want to impress your guests. This not only ensures that it’s cool when served, but your ingredients will also have time to blend together for an even better tasting macaroni salad! If you can, make this the night before and keep your macaroni chilled overnight. The best way to enjoy macaroni is when it’s cold! It’s recommended to keep it in the fridge for at least a few hours before serving. When it’s cooked, drain thoroughly and let it cool down to room temperature before mixing it in with the wet ingredients. You’re going to want the macaroni to be coated in dressing so make sure the pasta can hold it’s shape and not get mushy. Nobody likes soggy pasta! You want your macaroni al dente so make sure to boil it for no more than 9 minutes. Tips & Tricks For the Best Macaroni Saladįor the best macaroni salad to enjoy as a side dish or on it’s own, follow these tips and tricks! Ground black pepper – Freshly ground black pepper always has better flavor!.Salt – You can adjust the amount of salt you use.Prepared mustard – You can use regular yellow mustard but if you want a stronger, tangier dressing, go for Dijon mustard.Apple cider vinegar – Apple cider vinegar cuts through the richness of the dressing to create that perfect balance of creamy but slightly tangy.If you want your dressing extra creamy, go for whole egg mayonnaise! Mayonnaise – Mayo is what makes up most of the dressing so be sure to use good quality mayonnaise! If you want something slightly sweet, use regular mayonnaise.Chopped onion – Red onion works best for this recipe but if it’s too strong for you, you can also use white onion.Chopped red bell pepper – Red and green bell pepper tastes very similar but using both adds so much more color and flavor.If you love the taste of bell peppers, chop them bigger for more bite! Chopped green bell pepper – Just like celery, this will add a bit of crunch to your salad. ![]() When buying celery, check that the leaves aren’t wilted and that they are a bright green color. ![]() Chopped celery – Be sure to use celery that is fresh, firm, and crisp.Elbow macaroni (cooked and drained) – For perfectly cooked macaroni, make sure to bring your water to a boil first before adding the pasta.If you’re ready to make Grandma’s Macaroni Salad, gather up all your ingredients. ![]() Observed from a distance, the golden roofs glisten in the sunshine. ![]() The pagodas behind the temple are covered with gold on the top. At the doorway, the four-sided statue of roaring lions on the high column is golden. In the Jing'an Temple, the halls are copper-tiled. To tell the Buddhist stories, they are made up of jewels, corals, shells, jades and pearls according to their colors with golden foil stuck onto the lotus-shaped frames. The three-dimensional paintings on the back of the Buddhist statue are very exquisite and precious. Inside the Hall is enshrined the Tathagata statue made of 15 tons of silver. On the north side of the second floor is a great hall, the Mahavira Hall, which is to teach about Buddhism. On the east and west side of the second floor are many rooms for monks to do homework or perform ceremonies. However, the red drum and bell can only been seen from windows or through cracks. On either side of the Hall of Heavenly Kings are the Drum Tower and the Bell Tower. 1218 Middle Yanan Road, West Nanjing Road Level 1, Jing An Shangri-La, West Shanghai 0.3 miles from Jingan Temple Excellent experience at Shangr. On the second floor you can see a gate in the south, and the Hall of Heavenly Kings. However the Pagoda can only be seen from the outside. The top of the Pagoda is decorated with a Tibetan-style four-sided Pagoda, which enshrines 868 Buddhist statues and many esoteric treasures. It was too large to be brought into the Temple so that the temple gate had to be demolished in order to bring it in.Īt the north-west corner on the first floor is the Jing’an Pagoda. A 3.87 meter tall jade statue of Sakyamuni is enshrined in it and is larger than the jade Buddha in the Jade Buddha Building of the Jade Buddha Temple. The west wing room at the left side has the Muny Hall. Inside the Hall stands a 6.2 meter tall Bodhisattva statue made of millennial camphorwood. The First FloorĪt the right side on the first floor is the east wing room with the Bodhisattva Hall. There are two floors for you to visit from the bottom up. However in the Jing'an Temple, the Hall enshrining Bodhisattva is connected with the room for monks to do homework, encircling the square. In other temples, most halls are located on the medial axis. Subway lines: Take Line 2 or 7 and get off at the station of Jing'an Temple.Īfter you enter the temple, there is a square with a large censer cast with 15 tons of white copper in the center. For a fun night out, these cafes are fun Jing'an alternatives. You'll find a fun group of people ready to party sobriety style. At these two places you'll get cheap drinks and a fun atmosphere to hang out with friends.Ĭitizen Cafe and Always Cafe are great places for a fun night without booze. Tongren Road can be a bit of a wild night, and single men seem to populate the area on weekends.įor an affordable place to hang your hat while you drin, head to Windows Cafe and Pub or the I Love Shanghai Lounge. Nearby, Blue Frog is an establishment in Shanghai that serves great food and drinks, though at slightly elevated prices. Tongren Road also houses the amazing Big Bamboo, one of Shanghai's foremost sports bars. You'll find a rowdy group around the clock ready to party. There are a few key places you'll want to visit on Tongren Road, namely Malone's American Cafe, which is also a great place for American cuisine. Tongren Road is an amazing little bar street in Jing'An where you'll find several sports bars full of excited men. Some of the best restaurants are in Jing'An, and to compliment them the bars are equally fun and fascinating. Jing'An is an amazing place to stay, dance, drink and party. If you want a night out on the town where you can quickly stumble back to your hotel. Jing'An is right in the middle of the action. ![]() The first thing you notice here is that this could probably survive a nuclear attack- the all-steel componentry makes it the most durable option. Buy it now at Amazonĭynabrade Dynorbital-Spirit Non-Vacuum 5-Inch Random Orbital Sander -most durable Pro-tip: This DA is quite versatile and performs wonderfully on wood (with the correct paper) and plenty of other materials. The fact that it comes at a reasonable price is terrific news. Ingersoll-Rand is a well-known brand and this palm sander definitely lives up to its name! This is a heavy-duty tool and built to last for years. The air feed adjustment is another well thought out feature- it allows you to turn down the power a bit when you need. It’s a low vibration model, very quiet, and feels truly good in your hand- it comes with a variety of grip rings to match users’ hand sizes.Īnd with variable speed adjustment, you can sand at just the right speed. It’s actually an ever-present in many auto shops and we can easily see why. Simply plug it up to your air compressor and let it do the job- the tool needs about 8CFM minimum. In short, it won’t break a sweat when it comes to sanding your car down! This works super great, sands pretty fast (there’s tons of power in there), and you get an ultra-high-quality finish. Ingersoll-Rand Ultra Duty 6-Inch pad RandomOrbit Pneumatic Sander( Vacuum Ready) -126 Now, to give you more choice, our team has nominated three fantastic models to point you in the right direction. Best sander for car paint removal- the best air models to choose from Keep in mind that there are cordless sanders in the market too but they eat through batteries and don’t seem to give consistent performance. Table 1: Best sander for car paint removal ( air vs electric sander for auto body comparison) More powerful (With the right air compressor)Ī bit heavy because of the built-in motor We have summarized all the major positives and negatives in this table.īest for small jobs (no air compressor needed) The other decision you have to make when shopping for the best sander for car paint removal is whether to go for an air tool – a potent air compressor is a must because some are extremely hungry for air – or an electric DA model. We really don’t want to go into the technical stuff so here is what you should know as you shop around: a dual-action sander is the most formidable weapon against your old paint.įorget everything else! Pneumatic sander vs electric sander for car paint removal What is the best sander for car paint removal? I almost forgot to tell you that random orbital sanders make just one ‘type’ of motion – the variable random orbit pattern- and have one major advantage: they don’t leave swirl marks. The good news is that this gives you more options- use the locked rotation to sand fast or switch to orbital movement to reduce friction for a smoother finish. The second mode has the pad not only turning in a consistent motion without variance but it also oscillates in a random or non-predictable pattern (the spindle/pad will be in an unlocked position). In the first mode, the sanding pad rotates in a flat-plane orbit/circle (the pad is locked). Specifically, pads in a dual-action sander can move in two distinct ways: Orbital and Random orbital. Well, the most prominent differentiator is that the way the sanding pad moves. Many of you ask this question and we need to clear the air…. Best sander for car paint removal- our top picksĪ question before we go to our picks for the best sander for car paint removal: What is the difference between a D/A (Dual action) and a random orbital sander? ![]() Of course, taking this route needs two things: good technique and a great sander for car paint removal.Īnd while you’ll have to look elsewhere for the expertise, we will help you buy the best sander for car paint removal if you’re intent on tackling the job yourself. There are a couple of options- media blasting, paint-dissolving chemicals, and baking soda – but, sanding is often the easiest method, especially if your vehicle doesn’t have multiple layers of paint. Removing old paint will never be sexy but it’s your first step towards a concours appearance. As an Amazon affiliate, we earn a commision from qualifying purchases.įind our top picks for the best sander for car paint removal in this guide…. ![]() This may be useful in countries that block Facebook, for example. 8 Using Tor makes it more difficult to trace a user's Internet activity. 7 It directs Internet traffic via a free, worldwide, volunteer overlay network that consists of more than seven thousand relays. This allows you to access Facebook through Tor, and your connection doesn’t ever leave Tor where it can be snooped on. Tor, short for ' The Onion Router ,' 6 is free and open-source software for enabling anonymous communication. It also means that someone hosting a website can hide that server using the Tor network, so no one can find it–in theory.įor example, Facebook maintains an official Tor hidden services address at “facebookwkhpilnemxj7asaniu7vnjjbiltxjqhye3mhbshg7kx5tfyd.onion”. This means that your browsing activity can’t be snooped on by someone watching the Tor exit nodes. A “.onion” address points to a Tor hidden service, which is a server you can only access through Tor. RELATED: Is Tor Really Anonymous and Secure?īut that means that “last mile” of traffic can be snooped on by an organization monitoring or even running the exit nodes–especially if your traffic is unencrypted. Google sees this as the exit node’s IP address contacting it instead of your IP address. That exit node then contacts for you, and it sends you back the data Google responded with. So, when you access through Tor, your request bounces from Tor relay to Tor relay before it reaches an “exit node”. In addition to using TOR, we recommend the use of trusted. When you connect to Tor, your internet activity is sent through the Tor network, anonymizing your Internet activity so it can’t be snooped on, and so that you can access websites that may be blocked in your country. There are many ways to increase your personal security while using The Onion Router (TOR) browser. It’s partially funded by the US government, and is designed to help people in countries where Internet access may be censored or monitored. Tor–short for “the onion router”–is an anonymizing computer network. RELATED: How to Browse Anonymously With Tor |
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